CTLA-4 Expression in CD4+ T Cells From Patients With LRBA Deficiency and Common Variable Immunodeficiency With No Known Monogenic Disease
نویسندگان
چکیده
منابع مشابه
cd40 ligand expression on stimulated t-helper lymphocytes in patients with common variable immunodeficiency
common variable immunodeficiency (cvid) is the most common symptomatic primary antibody deficiency, characterized by reduced serum immunoglobulins levels and increased susceptibility to recurrent pyogenic infections. in this study, we evaluated cd40 ligand expression on stimulated versus unstimulated t-helper lymphocytes of nine common variable immunodeficient patients in comparison with fiftee...
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چکیده ندارد.
Elevated levels of activated CD4 T cells in common variable immunodeficiency: association with clinical findings.
BACKGROUND Common variable immunodeficiency (CVID) is a very heterogeneous syndrome defined by impaired immunoglobulin production. The primary defect remains unknown, but many reports describe peripheral blood T and B lymphocyte dysfunctions in a substantial proportion of CVID patients. Immunophenotypic alterations on memory B lymphocytes correlate with clinical findings. A B-cell-oriented clas...
متن کاملA 20-YEAR SURVEY OF INFECTIOUS COMPLICATIONS IN 64 PATIENTS WITH COMMON VARIABLE IMMUNODEFICIENCY
Common variable immunodeficiency (CV ID) is a heterogeneous primary immunodeficiency disorder, characterized by hypogammaglobulinemia and increased susceptibility to recurrent bacterial infections. To determine the spectrum of infectious complications in patients with common variable immunodeficiency (CV ID), we reviewed the hospital records of 64 CVID patients, who were diagnosed in Child...
متن کاملMurine LRBA deficiency causes CTLA-4 deficiency in Tregs without progression to immune dysregulation
Inherited mutations in lipopolysaccharide-responsive beige-like anchor (LRBA) cause a recessive human immune dysregulation syndrome with memory B-cell and antibody deficiency (common variable immunodeficiency), inflammatory bowel disease, enlarged spleen and lymph nodes, accumulation of activated T cells and multiple autoimmune diseases. To understand the pathogenesis of the syndrome, C57BL/6 m...
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ژورنال
عنوان ژورنال: Journal of Investigational Allergology and Clinical Immunology
سال: 2018
ISSN: 1018-9068
DOI: 10.18176/jiaci.0302